Hi Ajaya Kumar,

To dynamically change WebGrid layout, maybe you can populate the data in WebGrid OnInitializeDataSource event. Then you can clear cache data and retrieve its structure from data that you populate in OnPrepareDataBinding event. 

WebGrid1.ClearCachedDataSource();
WebGrid1.RetrieveStructure();

With this method, WebGrid structure will be the same as the data structure that you bind in OnInitializeDataSource event. WebGrid also doesn't have any limitation of users to perform this method. However, I don't really understand the specific scenario that you want to achieve. Could you explain me more detail about the scenario that you want to achieve? I will gladly help you to achieve it. Hope this helps.

Regards,
Bernard