Hi Mark,

It is simple, you forgot to have a logic behind your code. The issue occured because when you removed a column, OnInitializeLayout would be called again and your layout would be re rendered again. To avoid this, you need to add 'If(!ISPostBack)' on your code.

e.g

 protected void wgQuickPriceEntry_InitializeLayout(object sender, LayoutEventArgs e)
    {
        if (!IsPostBack)
        {
            e.Layout.AllowAddNew = AddNew.No;
            e.Layout.AllowColumnMove = ColumnMove.Yes;
            e.Layout.AllowColumnSizing = ColumnSizing.Yes;
            e.Layout.AllowColumnFreezing = ColumnFreezing.No;
            e.Layout.AllowContextMenu = true;
            e.Layout.AllowDelete = Delete.No;
            e.Layout.AllowEdit = Edit.Yes;
            e.Layout.AllowExport = Export.Yes;
            e.Layout.AllowFilter = Filter.Yes;
            e.Layout.AllowGrouping = Grouping.Yes;
            e.Layout.AllowSelectColumns = SelectColumns.Yes;
            e.Layout.AllowSorting = Sorting.Yes;
            e.Layout.ApplyFiltersKey = FilterKeyMode.Enter;
            e.Layout.AutoFilterSuggestion = true;
            e.Layout.ColumnFooters = ColumnVisibility.No;
            e.Layout.ColumnHeaders = ColumnVisibility.Yes;
            e.Layout.GroupByBoxVisible = true;
            e.Layout.HeaderClickAction = HeaderClick.SortMulti;
            e.Layout.InProgressUIBehavior = InProgressUIBehavior.ChangeCursorToHourGlass;
            e.Layout.PagingMode = PagingMode.VirtualLoad;
            e.Layout.PersistRowChecker = true;
            e.Layout.ShowFilterStatus = true;
            e.Layout.ShowRefreshButton = true;
            e.Layout.StatusBarVisible = true;
            e.Layout.VirtualLoadMode = VirtualLoadMode.Default;
            e.Layout.VirtualPageSize = 100;
            wgQuickPriceEntry.UseDefaultStyle = true;
            wgQuickPriceEntry.DefaultStyleMode = DefaultStyleKind.Elegant;
            e.Layout.FreezePaneSettings.ActiveFrozenColumns = 1;
            e.Layout.FreezePaneSettings.MaxFrozenColumns = 1;
            e.Layout.HideColumnsWhenGrouped = HideColumns.No;
            e.Layout.CellClickAction = CellClick.CellSelect;
            e.Layout.EditOnClick = true;
            // apply properties that cannot be modified
            e.Layout.AlwaysShowHelpButton = false;
            e.Layout.RowHeightDefault = new Unit("");
            for (int i = 1; i <= 50; i++)
            {
                wgQuickPriceEntry.RootTable.Columns.GetNamedItem("PL" + i).Visible = (i <= 4);
            }
        }
    }

Hope this helps.

Regards,
Handy

Thanks, this has resolved my issue.

Glad to hear that it solved your issue.

Regards,
Handy